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Magnesium
Research :
Articles on research, clinical trials, analysis,
reviews and empirical studies
Much
of the research cited herein will be found on PubMed, a
service of the National Library of Medicine. PubMed includes
over 15 million citations from MEDLINE and other life science
journals for biomedical articles back to the 1950s. PubMed
includes links to full text articles and other related resources.
Dietary
surveys suggest that many Americans do not consume magnesium
in the recommended amounts. Treatment with diuretics (water
pills), some antibiotics, and some medicine used to treat
cancer, such as Cisplatin, can increase the loss of magnesium
in urine. Poorly controlled diabetes increases loss of magnesium
in urine, causing a depletion of magnesium stores. Alcohol
also increases excretion of magnesium in urine, and a high
alcohol intake has been associated with magnesium deficiency.
Signs of magnesium deficiency include confusion, disorientation,
loss of appetite, depression, muscle contractions and cramps,
tingling, numbness, abnormal heart rhythms, coronary spasm,
and seizures.
Click
on the author's name to view the abstract
Dorup
I.
Magnesium and potassium deficiency. Its diagnosis, occurrence
and treatment in diuretic therapy and its consequences for
growth, protein synthesis and growth factors.
Acta Physiol Scand Suppl. 1994;618:1-55. Review.
Sojka
JE, Weaver CM. Magnesium supplementation and osteoporosis.
Nutr Rev. 1995 Mar;53(3):71-4.
Dimai HP, Porta S, Wirnsberger G, Lindschinger M, Pamperl
I, Dobnig H, Wilders-Truschnig M, Lau KH. Daily oral
magnesium supplementation suppresses bone turnover in young
adult males.
J Clin Endocrinol Metab. 1998 Aug;83(8):2742-8.
Kumeda
Y, Inaba M. Metabolic syndrome and Magnesium
Clin Calcium. 2005 Nov;15(11):97-104.
Shechter
M, Shechter A. Magnesium and myocardial infarction.
Heart Institute, Sheba Medical Center, Tel-Hashomer, Israel.
de
Araujo M, Andrade L, Coimbra TM, Rodrigues AC Jr, Seguro
AC.
Magnesium Supplementation Combined with N-Acetylcysteine
Protects against Postischemic Acute Renal Failure.
J Am Soc Nephrol. 2005 Nov;16(11):3339-49. Epub 2005 Sep
21. PMID: 16177005
Durlach
J, Pages N, Bac P, Bara M, Guiet-Bara A.
Magnesium depletion with hypo- or hyper- function of the
biological clock may be involved in chronopathological forms
of asthma. Magnes Res. 2005 Mar;18(1):19-34.
PMID: 15945613 [PubMed - indexed for MEDLINE]
Singewald
N, Sinner C, Hetzenauer A, Sartori SB, Murck H.
Magnesium-deficient diet alters depression- and anxiety-related
behavior in mice--influence of desipramine and Hypericum
perforatum extract.
Neuropharmacology. 2004 Dec;47(8):1189-97.
Additional
research and articles on Magnesium:
Diabetes
Hypomagnesemia
in Type II Diabetes: Effect of a 3-Month Replacement Therapy.
Eibl NL, Kopp HP, Nowak HR, Schnack CJ, Hopmeier PG, Schernthaner
G.
Diabetes Care. 1995 Feb;18(2):188-92.
Role
of Magnesium in Insulin Action, Diabetes, and Cardio-Metabolic
Syndrome
Barbagallo M, Dominguez LJ, Galioto A, Ferlisi A, Cani C,
Malfa L, Pineo A, Busardo' A, Paolisso G.
Mol Aspects Med. 2003 Feb-Jun; 24 (1-3):39-52.
Dietary
Magnesium Intake in Relation to Plasma Insulin Levels and
Risk of Type 2 Diabetes in Women.
Song Y, Manson JE, Buring JE, Liu S.
Diabetes Care. 2004 Jan;27 (1): 59-65
Magnesium
Intake and Risk of Type 2 Diabetes in Men and Women.
Lopez-Ridura R, Willett WC, Rimm EB, Liu S, Stampfer MJ,
Manson JE, Hu FB.
Diabetes Care. 2004 Jan;27 (1) 134-40.
Magnesium
deficiency and diabetes.
Campbell RK, Nadler J.
Diabetes Educ. 1992 Jan-Feb;18(1):17-9.
Effects
of oral magnesium supplementation on plasma lipid concentrations
in patients with non-insulin-dependent diabetes mellitus.
Corica F, Allegra A, Di Benedetto A, Giacobbe MS, Romano
G, Cucinotta D, Buemi M, Ceruso D.
Magnes Res. 1994 Mar;7(1):43-7.
Heart
Health
Oral
magnesium supplementation inhibits platelet-dependent thrombosis
in patients with coronary artery disease.
Shechter M, Merz CN, Paul-Labrador M, Meisel SR, Rude RK,
Molloy MD, Dwyer JH, Shah PK, Kaul S.
Am J Cardiol. 1999 Jul 15;84(2):152-6.
Oral
magnesium therapy improves endothelial function in patients
with coronary artery disease.
Shechter M, Sharir M, Labrador MJ, Forrester J, Silver B,
Bairey Merz CN.
Circulation. 2000 Nov 7;102(19):2353-8.
Magnesium
and cardiovascular biology: an important link between cardiovascular
risk factors and atherogenesis.
Altura BM, Altura BT.
Cell Mol Biol Res. 1995;41(5):347-59.
Magnesium
and cardiovascular disease.
Arsenian MA.
Prog Cardiovasc Dis. 1993 Jan-Feb;35(4):271-310.
Low
intracellular magnesium levels promote platelet-dependent
thrombosis in patients with coronary artery disease.
Shechter M, Merz CN, Rude RK, Paul Labrador MJ, Meisel SR,
Shah PK, Kaul S.
Am Heart J. 2000 Aug;140(2):212-8.
Effects
of magnesium supplementation in hypertensive patients: assessment
by office, home, and ambulatory blood pressures.
Kawano Y, Matsuoka H, Takishita S, Omae T.
Hypertension. 1998 Aug;32(2):260-5.
Antiarrhythmic
effects of increasing the daily intake of magnesium and
potassium in patients with frequent ventricular arrhythmias.
Magnesium in Cardiac Arrhythmias (MAGICA) Investigators.
Zehender M, Meinertz T, Faber T, Caspary A, Jeron A, Bremm
K, Just H.
J Am Coll Cardiol. 1997 Apr;29(5):1028-34.
Magnesium
in the pathophysiology and treatment of hypertension and
diabetes mellitus: where are we in 1997?
Resnick LM. Am J Hypertens. 1997 Mar;10(3):368-70.
Relation
between severity of magnesium deficiency and frequency of
anginal attacks in men with variant angina.
Satake K, Lee JD, Shimizu H, Ueda T, Nakamura T.
J Am Coll Cardiol. 1996 Oct;28(4):897-902.
Epidemiological
studies on the relationship between magnesium intake and
cardiovascular diseases.
Karppanen H. Artery. 1981;9(3):190-9.
Overall
Benefits of Magnesium
Magnesium
and therapeutics.
Durlach J, Durlach V, Bac P, Bara M, Guiet-Bara A.
Magnes Res. 1994 Dec;7(3-4):313-28.
Oral
Magnesium Oxide Prophylaxis of Frequent Migrainous Headache
in Children: A Randomized, Double-Blind, Placebo-Controlled
Trial.
Wang F, Van Den Eeden SK, Ackerson LM, Salk SE, Reince RH,
Elin RJ.
Headache. 2003 Jun;43 (6): 601-10.
Women's
Health
Interrelationship
of magnesium and estrogen in cardiovascular and bone disorders,
eclampsia, migraine and premenstrual syndrome.
Seelig MS. J Am Coll Nutr. 1993 Aug;12(4):442-58.
The
effect of oral magnesium substitution on pregnancy-induced
leg cramps.
Dahle LO, Berg G, Hammar M, Hurtig M, Larsson L.
Am J Obstet Gynecol. 1995 Jul;173(1):175-80.
Increased
need for magnesium with the use of combined estrogen and
calcium for osteoporosis treatment.
Seelig MS. Magnes Res. 1990 Sep;3(3):197-215.
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