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Much of the research cited herein will be found on PubMed, a service of the National Library of Medicine. PubMed includes over 15 million citations from MEDLINE and other life science journals for biomedical articles back to the 1950s. PubMed includes links to full text articles and other related resources. Click on the author's name to read the abstract. [See research on other minerals.]
Dietary surveys suggest that many Americans do not consume magnesium in the recommended amounts. Treatment with diuretics (water pills), some antibiotics, and some medicine used to treat cancer, such as Cisplatin, can increase the loss of magnesium in urine. Poorly controlled diabetes increases loss of magnesium in urine, causing a depletion of magnesium stores. Alcohol also increases excretion of magnesium in urine, and a high alcohol intake has been associated with magnesium deficiency. Signs of magnesium deficiency include confusion, disorientation, loss of appetite, depression, muscle contractions and cramps, tingling, numbness, abnormal heart rhythms, coronary spasm, and seizures.
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Dimai HP, Porta S, Wirnsberger G, Lindschinger M, Pamperl I, Dobnig H, Wilders-Truschnig M, Lau KH. Daily oral magnesium supplementation suppresses bone turnover in young adult males. J Clin Endocrinol Metab. 1998 Aug;83(8):2742-8.
Kumeda Y, Inaba M. Metabolic syndrome and Magnesium Clin Calcium. 2005 Nov;15(11):97-104.
Shechter M, Shechter A. Magnesium and myocardial infarction. Heart Institute, Sheba Medical Center, Tel-Hashomer, Israel.
de Araujo M, Andrade L, Coimbra TM, Rodrigues AC Jr, Seguro AC. Magnesium Supplementation Combined with N-Acetylcysteine Protects against Postischemic Acute Renal Failure. J Am Soc Nephrol. 2005 Nov;16(11):3339-49. Epub 2005 Sep 21. PMID: 16177005
Singewald N, Sinner C, Hetzenauer A, Sartori SB, Murck H. Magnesium-deficient diet alters depression- and anxiety-related behavior in mice--influence of desipramine and Hypericum perforatum extract. Neuropharmacology. 2004 Dec;47(8):1189-97.
Eibl NL, Kopp HP, Nowak HR, Schnack CJ, Hopmeier PG, Schernthaner G. Diabetes Care. 1995 Feb;18(2):188-92. Hypomagnesemia in Type II Diabetes: Effect of a 3-Month Replacement Therapy.
Barbagallo M, Dominguez LJ, Galioto A, Ferlisi A, Cani C, Malfa L, Pineo A, Busardo' A, Paolisso G., Role of Magnesium in Insulin Action, Diabetes, and Cardio-Metabolic Syndrome Mol Aspects Med. 2003 Feb-Jun; 24 (1-3):39-52.
Song Y, Manson JE, Buring JE, Liu S., Dietary Magnesium Intake in Relation to Plasma Insulin Levels and Risk of Type 2 Diabetes in Women. Diabetes Care. 2004 Jan;27 (1): 59-65
Lopez-Ridura R, Willett WC, Rimm EB, Liu S, Stampfer MJ, Manson JE, Hu FB., Magnesium Intake and Risk of Type 2 Diabetes in Men and Women. Diabetes Care. 2004 Jan;27 (1) 134-40.
Shechter M, Sharir M, Labrador MJ, Forrester J, Silver B, Bairey Merz CN. Oral magnesium therapy improves endothelial function in patients with coronary artery disease. Circulation. 2000 Nov 7;102(19):2353-8.
Shechter M, Merz CN, Rude RK, Paul Labrador MJ, Meisel SR, Shah PK, Kaul S. ,, Low intracellular magnesium levels promote platelet-dependent thrombosis in patients with coronary artery disease.Am Heart J. 2000 Aug;140(2):212-8.
Wang F, Van Den Eeden SK, Ackerson LM, Salk SE, Reince RH, Elin RJ., Oral Magnesium Oxide Prophylaxis of Frequent Migrainous Headache in Children: A Randomized, Double-Blind, Placebo-Controlled Trial. Headache. 2003 Jun;43 (6): 601-10.
Seelig MS., Interrelationship of magnesium and estrogen in cardiovascular and bone disorders, eclampsia, migraine and premenstrual syndrome. J Am Coll Nutr. 1993 Aug;12(4):442-58.
Dahle LO, Berg G, Hammar M, Hurtig M, Larsson L. The effect of oral magnesium substitution on pregnancy-induced leg cramps. Am J Obstet Gynecol. 1995 Jul;173(1):175-80.
Seelig MS. Increased need for magnesium with the use of combined estrogen and calcium for osteoporosis treatment. Magnes Res. 1990 Sep;3(3):197-215.
Silica
Some of the most common symptoms of deficiency are brittle nails, loss of hair, poor skin quality, Arthritis, Osteoporosis, and stomach ailments.
Common ailments from allergies to hip dysplasia are maladies plaguing animals today, but the proper mineral supplementation can bring much needed relief. Eidon minerals are liquid, taste-free, and easily absorbed right from your pet's drinking water.